What is the recommended dose?
Lorazepam is commonly available as tablets which can be administered orally. Along with lorazepam, Generic Ativan also contains lactose, magnesium stearate, microcrystalline cellulose,and some coloring agents. The peak effect of this drug is seen in 90 minutes to 2 hours if taken orally and will be effective for almost 6 to 12 hours. It is prescribed 2 to 4 times a day when received on a regular basis. The dosage of the drug can be altered by the physician according to the age of the patient.
How does this drug act on the body?
The active ingredient of generic Ativan is lorazepam which is highly bounded to protein (around 85 to 90 %). If taken by mouth, the absorption of the drug is slowest due to its poor lipid solubility. Lorazepam gives prolonged peak effect as the volume distribution of drug occurs mainly in the vascular space. Lorazepam is highly effective than any other benzodiazepine so there is less need for repeated doses. The inactive ingredient which is conjugated by lorazepam is lorazepam glucuronide. The drug is metabolized in the liver and is excreted through urine. This drug has high empathy for GABA receptors and its main function is to increase the effect of GABA at its receptors. GABA is a neurotransmitter which increases the number of chloride ion channels opening on the receptors which result in the therapeutic effect of the drug. This drug shows anticonvulsant properties due to the binding of the drug to sodium channels.
What are the harmful effects of lorazepam?
There are many benefits of lorazepam but when these benefits are not needed in the body, they may lead to few adverse effects. The adverse effects of this drug are,
The side effects of the lorazepam are seen on the higher rate, when taken in combination with the CNS depressant drugs and also depends on the dosage of the drug. Therefore, it is always advised to start these drugs with smaller dose as over dosage may lead to fatal conditions.
In which conditions lorazepam should not be administered?
Generic Ativan should be avoided in conditions like,
Past history of allergy to lorazepam or any other benzodiazepines.
Acute severe asthma
Ataxia which happens due to the failure of muscle coordination and is evidently noticed on standing and walking
Acute narrow-angle glaucoma. This drug has a pupil dilating effect and can harm the drainage of aqueous humour from the chamber placed in the anterior portion of the eye.
Sleep apnea is noticed due to increased CNS depressant effects of lorazepam.
Muscle weakness which is the main characteristic of my asthenia gravis.
This drug should not be taken during pregnancy and especially during the third trimester as it may cause floppy infant syndrome and may lead to other dangerous conditions if received without consulting a doctor.
This drug should be cautiously used for children and elderly patients. It's not very effective for children under the age of 18 years but is commonly used for treating the acute seizures. In elderly patients, the risk of oversedation is higher so long term therapy should be avoided for such patients. Generic Ativan also accumulates in the body of elderly patients if received for the long term as the metabolic rate decreases with the age.
Know what happens in case of over-dosage of the drug:
Over dosage or long term treatment causes drug dependence and addiction. Benzodiazepines like lorazepam, alprazolam,and triazolam are known for drug dependence if overused. The signs which are commonly noticed due to overdosage of the drug are,
Overdosage of the drug should be managed immediately if noticed by including emetics, activated charcoal and gastric lavage along with continuous observation of vital signs. In severe conditions, flumazenil can also be used for the management but before using one must note the side effects of it. The drug should be stopped or dose should be altered very carefully as the patient can experience withdrawal symptoms on sudden stoppage of the drug.
Which drugs interact with Ativan?
Benzodiazepines are highly interactive with some other medicines so before consuming any drugs along with this one should talk to a health care professional for receiving better treatment without any complications and side effects. Lorazepam effects harmfully if taken with alcohol. Therefore, alcohol consumption should be avoided during treatment. Drugs like opioids, rifabutin, valproate, carbamazepine, phenobarbital, rifampin interact with lorazepam. Some drugs alter the rate of metabolism florazepam in the body and drugs such as opioids show synergistic effects and also increases sedative effect so advised to take it cautiously.
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