The composition of the drug
There are active and inactive ingredients present in the medicine. With active ingredient diazepam, inactive ingredients like anhydrous lactose, corn starch, pregelatinized starch, calcium stearate, and dyes are also present.
Medical uses of the drug
Diazepam is importantly used for acute anxiety disorder which includes panic attacks and is also useful for acute alcohol withdrawal. It is also used for the short term treatment of insomnia and as a premedication before some medical procedures. It is used for muscle spasms as they show muscle relaxant properties and for the treatment of complications with hallucinogen crises, LSD etc. It is also used for oxygen toxicity during the therapy of hyperbaric oxygen. It is the first line treatment for status epilepticus as it produces an anticonvulsant effect. Sometimes diazepam is also used for febrile seizures which occur in children under the age of five years.
Mechanism of action
When diazepam is taken orally with a meal, it is absorbed in 45 minutes and within 15 minutes when fasting. In adults, the clearance of the drug is 20 to 30 ml per minute and half-life of this is up to 48 hours. In children of 3 to 8 years of age, the half-life is of 18 hours. And in infants, it is for 30 hours. This drug calms the brain and the nerves as it binds to receptors in the central nervous system and also it may increase the effect of gamma-aminobutyric acid.
Generic Valium (diazepam) should be received carefully as it pharmacologically interacts with other drugs and can affect the mental and physical health of the person. Diazepam interacts with sedatives, antipsychotics, anticonvulsants, hypnotics, antihistamines, anesthetics, barbiturates, narcotics, antidepressants, etc. It should not be consumed with alcohol as it enhances the sedative effect of the drug. The effect of diazepam is also reduced to 30 percent when consumed with antacids. One should not start or stop the drug usage without doctors approval and also it is important to inform the doctor before changing the dosage as it may lead to severe side effects.
Diazepam is not indicated in individuals with,
Nursing mothers (diazepam passes into breast milk)
Known hypersensitivity to diazepam
Severe respiratory insufficiency
Sleep apnea syndrome
Acute narrow-angle glaucoma
Severe renal insufficiencies like patients on dialysis
History of alcohol or drug dependence
Overdosage of the drug
It is not recommended to consume generic valium (diazepam) for the long term, hence the dosage should be altered accordingly and cautiously by the physician for the maximum effect avoiding the adverse effects. Overdosage may lead to harmful conditions which mainly include central nervous system depression, therefore should be managed immediately if experienced. Drug tolerance and dependence can be noticed if used for long term and harmful symptoms are indicated on sudden withdrawal of the medicine. Withdrawal symptoms such as sweating, anxiety, muscle cramps, vomiting, shaking, restlessness, seizures etc. are experienced. Limited dosage should be administered by elderly patients is 2 mg to 2.5 mg once or twice daily.
Most of the individuals do not experience any serious problem or side effect of the drug but some side effects commonly noticed are drowsiness, muscle weakness, tiredness, ataxia, headache, depression, nausea, constipation, dizziness, hypotension, hyperexcitation, insomnia, sleepiness, blurred vision and trouble with coordination. In the presence of epilepsy, there is a high risk of seizures if diazepam is used frequently. If skin reactions, irritability, nightmares, and any other behavioral effects are noticed then the drug should be discontinued immediately. The benefit should always be more than the risk of side effects of the drug to the body.
The doctor should be informed about the allergies if present and proper medical history should be taken before receiving Generic Valium. Activities which requires alertness and cleared vision such as driving, etc. should be avoided. One should strictly avoid alcohol consumption as it may worsen the effects. For some children and adults, diazepam may show the opposite effect instead of calming effect which increases the risk of falling. In such cases immediately stop the medicine and inform the doctor. It is not recommended during pregnancy and for nursing mothers. If you are on medication then consult your doctor before breastfeeding.
Drug addicts and alcoholics should be under supervision when receiving Generic Valium (diazepam) to avoid the dependency on the drug. In such patients, there are adverse symptoms noticed while discontinuing the drug. It is advised to consult a health care expert before altering the drug dosage or discontinuing the drug. Psychotic patients are not advised to receive this medicine without consulting the doctor as it may lead to severe depression. Abruptly stopping the drug after long term use, there are many problems related to intellectual functions which are noticed for almost six months or more. Pediatric patients less than 18 years of age are commonly not advised to receive this treatment except for the individuals with epilepsy and also for the pre and postoperative treatment where the smallest dose is used for such patients.
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